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Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
Chuapoco, Flytzanis, Goeden, et al
Nature Nanotechnology, July 2023
Posters from the American Society for Gene & Cell Therapy Annual Meeting – 2023
- Optimization of a Versatile Downstream Process for Multiple Novel AAV Capsids That Demonstrates Improved Recovery – Download PDF
- Exploring upstream process conditions to improve productivity for novel AAV Capsids – Download PDF
- Development and Comparative Assessment of a Rapid, High-Throughput Method for Accurate Quantification of Host Cell DNA Impurities in Final Drug Product and Process Intermediates – Download PDF
Posters from the American Society for Gene & Cell Therapy Annual Meeting – 2022
- Optimization of a scalable upstream process for production of novel AAV capsids – Download PDF
- Manufacturability and product quality of novel AAV capsids optimized for specific targeting using capsid library selection in non-human primates – Download PDF
- Next-generation automated AAV engineering platform for rapid identification of efficient and specific capsids in non-human primates – Download PDF
- Multiple generations of capsids engineered in NHPs yield improved performance in the central nervous system – Download PDF
- Combinatorial engineering across multiple surface exposed loops of AAV2 and AAV9 yields capsids with high degrees of enrichment and specificity for target tissues – Download PDF
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
Goertsen, Flytzanis, Goeden et al
Nature Neuroscience, January 2022
Intravenous gene transfer throughout the brain of infant Old World primates using AAV
Chuapoco, Flytzanis, Goeden et al
biorxiv, January 2022